2026 ACC/AHA Guidelines for Acute Pulmonary Embolism

The ACC/AHA published new guidelines for managing acute PE on February 19, 2026. Today I'm joined by Dr. Scott Woller, MD, MACP, FCCP, who was co-chair of the American College of Chest Physicians Clinical Practice Guideline for antithrombotic therapy for venous thromboembolism, last updated in 2021. He also served as co-chair for the peer review committee for these new guidelines, and has lots of great insights into how to use them in clinical practice and research. 2026 ACC/AHA Guidelines for Diagnosis and Managing Acute PE Some highlights from the guidelines: New categories of PE: A: asymptomatic B: symptomatic, low risk C: symptomatic, high risk D: incipient shock E: cardiogenic shock PE response teams (PERTs) are ascendant Use enoxaparin instead of heparin drip! Advanced therapies for category D and E Half dose DOACs for extended treatment Shared decision making for clots provoked by minor risk factors Patients with persistent symptoms need evaluation for CTEPD Music from Uppbeat (free for Creators!): https://uppbeat.io/t/soundroll/dope License code: NP8HLP5WKGKXFW2R