#148 - Meet The Ibogaine Psychedelic Scientist Who First Unravelled Its Big Mystery

🧠 JOIN THE GIANT’S SHOULDER FAMILY Become a YouTube Member for exclusive episodes, early access + ad-free viewing: https://www.youtube.com/@thegiantsshoulder/join Deborah Mash is a neuropharmacologist who holds the first FDA licence ever granted to give ibogaine to a human being, built one of America's largest brain banks, and discovered noribogaine — the metabolite now entering its first US clinical trial. She has spent over thirty years on a drug that appears to interrupt addiction after a single dose. This April a US president named it specifically. This is the scientist who was right three decades early. Expect to learn what Trump's executive order actually changes for ibogaine, why Sasha Shulgin put ibogaine in a box of its own, how noribogaine blocks nicotine, alcohol, cocaine and opioid use in animal models, why ibogaine holds the brain's neuroplasticity window open for four weeks when ketamine manages days, why some patients get the full therapeutic benefit with no psychedelic experience at all, why the reported ibogaine deaths are almost impossible to interpret, why more than 80% of her patients said they never wanted to repeat it, and much more... SPONSORS Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulder Join the Outskill AI Mastery Sprint (Free This Weekend) - https://links.outskill.com/GIASHOULAUG2GS EPISODES MENTIONED David Nutt - Meet the Neuroscientist Fired For Exposing the Truth! Dr David Nutt: https://youtu.be/BLk6a5Vb2O0 David Nutt - Neuroscientist Ranks Every Drug By How Hard They Are to Quit! Tier List: https://youtu.be/G-OZ_UBGvvo GUEST LINKS University of Miami Faculty Profile: http://neurology.med.miami.edu/about-us/faculty-list/deborah-c-mash-ph-d X: https://x.com/drdeborahmash Google Scholar: https://scholar.google.com/citations?user=4383E7wAAAAJ&hl=en DemeRx: https://www.demerx.com/team/deborah-c-mash-phd/ 2018 Frontiers in Pharmacology paper (St. Kitts cohort): https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.00529/full Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about FOLLOW EVAN https://x.com/evan_mcgl TIMESTAMPS 0:00:00 Trailer 0:02:00 Why Ibogaine Is Suddenly Everywhere 0:02:22 Trump's Executive Order and What It Actually Does 0:05:55 The Drug That Breaks the Cycle of Addiction 0:08:07 Why One Drug Treats Addiction, Depression and Trauma 0:11:30 Noribogaine: The Metabolite Nobody Talks About 0:14:20 The Real Risks Nobody Reports Properly 0:16:36 How Ibogaine Became a Vast Underground Experiment 0:17:44 Veterans, Brain Trauma and the Testimonials 0:22:55 The Master Molecule: Why Ibogaine Stands Alone 0:23:30 Sasha Shulgin Draws Four Boxes 0:26:48 Is a Psychedelic Just a Hard Reboot? 0:28:11 Four Weeks of Neuroplasticity, Longer Than Anything Else 0:28:44 Fast, Slow and Ultra-Rapid Metabolisers 0:31:39 The First Patient in St. Kitts, Decades Later 0:34:35 Do You Need the Trip to Reach the Destination? 0:35:05 One Molecule, Every Addiction 0:37:39 Miami Vice and the Bodies at the Morgue 0:41:18 The Man Who Slept Through His Own Trip 0:44:11 Why America Will Lead on Ibogaine 0:47:51 Dual Dosing: The Second Stage of the Rocket 0:54:52 Why More Than 80% Never Want to Repeat It 0:57:33 What Would Ibogaine Do to a Healthy Brain? 0:58:18 Why She's Never Taken Ibogaine 0:59:39 Psychedelics, Longevity and Ageing Brains ......Email for sponsorship enquiries: evan@thegiantsshoulder.com