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Artwork for Dr. John Campbell
Dr. John Campbell · August 19 · 28 min

Vaccines, third doses required

United States, White House team, Boosters start September https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases https://covid.cdc.gov/covid-data-tracker/#vaccination-trends https://covid.cdc.gov/covid-data-tracker/#hospitalizations (FDA depending) Eight months after Pfizer or Moderna Same brand News on second dose of J and J in the next few weeks Mr. Greg Abbott in Texas Tested positive for COVID-19 on Tuesday Is in good health and experiencing no symptoms Mr. Abbott was vaccinated in December All close contacts being notified May not always have been wearing a mask recently Seven million who are immunocompromised Booster roll out started in Detroit yesterday Children Cases, + 121,427 in past 7 days Hospital admissions, x 3 in past 7 days Predictive indicators seem to have changed Data from Israel Health Ministry https://www.medrxiv.org/content/10.1101/2021.07.29.21261317v1.full.pdf N = 2.5 million (16 and over) Second dose administered within the 21 to 28 day interval set by national guidelines A significant drop in protection against hospitalization among people age 65 and older Who were vaccinated in January and February Delta (B.1.617.2) variant became the dominant strain in Israel in June 2021 Israel is currently experiencing a new surge of cases The correlation between antibody dynamics and clinical protection remains undefined Correlation between time-from-vaccine and incidence of breakthrough infection We found that the risk for infection was significantly higher for early vaccinees compared to those vaccinated later Model 1 We matched 329,177 persons in each group 1,911 cases of breakthrough infection were recorded 1,151 of them in the Early Vaccinees group 760 in the Late Vaccinees group We found a statistically significant 53% increased risk for breakthrough infection in early vaccines (P less than 0.001) We found a similar trend across all age groups Model 2 Individuals who were vaccinated in January 2021 Had a 2.26-fold increased risk for breakthrough infection Compared to individuals who were vaccinated in April 2021 Israel has already started beginning giving booster shots to people older than 50. Data on all symptomatic sequenced cases of Covid-19 in England Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant https://www.nejm.org/doi/full/10.1056/NEJMoa2108891 After one dose of Pfizer or AZ, delta efficacy = 31% After one dose of Pfizer or AZ, alpha efficacy = 49% After two dose of Pfizer, alpha efficacy = 94% After two dose of Pfizer, delta efficacy = 88% After two dose of AZ, alpha efficacy = 75% After two dose of AZ, delta efficacy = 67% Data from Qatar BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the Delta (B.1.617.2) variant in Qatar https://www.medrxiv.org/content/10.1101/2021.08.11.21261885v1 Effectiveness against any severe, critical, or fatal COVID-19 disease due to delta was 89.7% Both BNT162b2 (Pfizer) and mRNA-1273 (Moderna) are highly effective in preventing Delta hospitalization and death, but less so in preventing infection (Moderna may protect against symptomatic infection more than Pfizer) Paul A. Offit, pediatrician and vaccine expert at Children’s Hospital of Philadelphia https://www.washingtonpost.com/health/breakthrough-infections-covid-vaccine/2021/08/17/44ebcaaa-fea0-11eb-85f2-b871803f65e4_story.html We could have done a much better job at setting realistic expectations for this vaccine And I think that’s hurt us. Because I think people get disappointed. They think the vaccine isn’t working.” Centers for Disease Control and Prevention (Leaked PP) https://www.cdc.gov/mmwr/volumes/70/wr/mm7031e2.htm?s_cid=mm7031e2_w https://edition.cnn.com/2021/07/30/health/breakthrough-infection-masks-cdc-provincetown-study/index.html July 29, 35,000 breakthrough infections a week CDC Di Learn more about your ad choices. Visit megaphone.fm/adchoices

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United States, White House team, Boosters start September https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases https://covid.cdc.gov/covid-data-tracker/#vaccination-trends https://covid.cdc.gov/covid-data-tracker/#hospitalizations (FDA depending) Eight months after Pfizer or Moderna Same brand News on second dose of J and J in the next few weeks Mr. Greg Abbott in Texas Tested positive for COVID-19 on Tuesday Is in good health and experiencing no symptoms Mr. Abbott was vaccinated in December All close contacts being notified May not always have been wearing a mask recently Seven million who are immunocompromised Booster roll out started in Detroit yesterday Children Cases, + 121,427 in past 7 days Hospital admissions, x 3 in past 7 days Predictive indicators seem to have changed Data from Israel Health Ministry https://www.medrxiv.org/content/10.1101/2021.07.29.21261317v1.full.pdf N = 2.5 million (16 and over) Second dose administered within the 21 to 28 day interval set by national guidelines A significant drop in protection against hospitalization among people age 65 and older Who were vaccinated in January and February Delta (B.1.617.2) variant became the dominant strain in Israel in June 2021 Israel is currently experiencing a new surge of cases The correlation between antibody dynamics and clinical protection remains undefined Correlation between time-from-vaccine and incidence of breakthrough infection We found that the risk for infection was significantly higher for early vaccinees compared to those vaccinated later Model 1 We matched 329,177 persons in each group 1,911 cases of breakthrough infection were recorded 1,151 of them in the Early Vaccinees group 760 in the Late Vaccinees group We found a statistically significant 53% increased risk for breakthrough infection in early vaccines (P less than 0.001) We found a similar trend across all age groups Model 2 Individuals who were vaccinated in January 2021 Had a 2.26-fold increased risk for breakthrough infection Compared to individuals who were vaccinated in April 2021 Israel has already started beginning giving booster shots to people older than 50. Data on all symptomatic sequenced cases of Covid-19 in England Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant https://www.nejm.org/doi/full/10.1056/NEJMoa2108891 After one dose of Pfizer or AZ, delta efficacy = 31% After one dose of Pfizer or AZ, alpha efficacy = 49% After two dose of Pfizer, alpha efficacy = 94% After two dose of Pfizer, delta efficacy = 88% After two dose of AZ, alpha efficacy = 75% After two dose of AZ, delta efficacy = 67% Data from Qatar BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the Delta (B.1.617.2) variant in Qatar https://www.medrxiv.org/content/10.1101/2021.08.11.21261885v1 Effectiveness against any severe, critical, or fatal COVID-19 disease due to delta was 89.7% Both BNT162b2 (Pfizer) and mRNA-1273 (Moderna) are highly effective in preventing Delta hospitalization and death, but less so in preventing infection (Moderna may protect against symptomatic infection more than Pfizer) Paul A. Offit, pediatrician and vaccine expert at Children’s Hospital of Philadelphia https://www.washingtonpost.com/health/breakthrough-infections-covid-vaccine/2021/08/17/44ebcaaa-fea0-11eb-85f2-b871803f65e4_story.html We could have done a much better job at setting realistic expectations for this vaccine And I think that’s hurt us. Because I think people get disappointed. They think the vaccine isn’t working.” Centers for Disease Control and Prevention (Leaked PP) https://www.cdc.gov/mmwr/volumes/70/wr/mm7031e2.htm?s_cid=mm7031e2_w https://edition.cnn.com/2021/07/30/health/breakthrough-infection-masks-cdc-provincetown-study/index.html July 29, 35,000 breakthrough infections a week CDC Di

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