
Core IM | Internal Medicine Podcast · Dec 10, 2025 · 21 min
#195 Antibiotic Duration & BALANCE Trial: Beyond Journal Club with NEJM Group
0:00-21:44
transcript
show notes
Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit how 1) host, 2) organism, and 3) source should guide treatment. When shorter really is enough, and when it isn’t?
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Timestamp
(02:58) | Host, Organism, Source: The Core Framework Behind Duration
(09:02) | How Evidence Shifted Practice
(11:27) | The BALANCE Trial: Short-Course vs Standard-Course Therapy
(18:55) | Where does this leave us?
Tags: CoreIM, Internal Medicine, Infectious disease, Evidence-Based Medicine, Clinical Reasoning, Hospital Medicine, Medical Education
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