Clinical Chemistry Podcast

Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility

Juexiao Sherry Wang, C J Battey, Kyle Trettin, Ravi Patel, Anu Srinivasan, Janani Saikumar, Divya Kushnoor, Ben F Habermeyer, Sangita Ganesh, Nafei Xu, Nathaniel Friedrich, Summer Pierson, Helen Wan, Heather LaBreche, Genevieve M Gould, Dale Muzzey. Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 679–691. https://doi.org/10.1093/clinchem/hvag005

Audio Summary August 2026

From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians

Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages 814–816. https://doi.org/10.1093/clinchem/hvag044

Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis

Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 575–582. https://doi.org/10.1093/clinchem/hvaf187

Audio Summary July 2026

DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping

Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 662–669. https://doi.org/10.1093/clinchem/hvag007.

Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions

Lisa A Lansdon, Binu Porath, Mari Mori, David T Miller, Diane Dunham Drexler, Catherine Wattenberg, Morgan Richardson, Robert D Steiner, Peter J Freeman. Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 652–661. https://doi.org/10.1093/clinchem/hvag010

Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine

Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 546–553. https://doi.org/10.1093/clinchem/hvag014

Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring

Grace Drew, Colleen S Kraft, Nirja Mehta. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 554–563. https://doi.org/10.1093/clinchem/hvaf156

Audio Summary June 2026

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

Andrea L Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduña Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas J Ashton. Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 303–315, https://doi.org/10.1093/clinchem/hvaf162

Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis

Denise M O'Sullivan, Gerwyn M Jones, Manca Zolnir-Dovc, Richard Phillips, Rejoice Arthur, Bariki Mtafya, Daniel Adon Mapamba, Daniela Maria Cirillo, Ewa Augustynowicz-Kopeć, Mei Mei Ho, Belinda Dagg, Sven O Friedrich, Francesca Colavita, Antonella Vulcano, Prince Asare, Dorothy Yeboah-Manu, Timothy D McHugh, Jim F Huggett. Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 390–397. https://doi.org/10.1093/clinchem/hvaf178

Audio Summary May 2026

Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets

Thomas J S Durant, Seung Joo Lee, Sarah N Dudgeon, Elizabeth Knight, Brent Nelson, H Patrick Young, Lucila Ohno-Machado, Wade L Schulz. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 451–460. https://doi.org/10.1093/clinchem/hvaf192

Scientific Fraud at Scale: Challenges for Trust in Published Data

Preejith P Vachali, Adam J McShane. Scientific Fraud at Scale: Challenges for Trust in Published Data. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 518–519. https://doi.org/10.1093/clinchem/hvag002

Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing

Yusheng Zhu, Jarrett Sell. Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 439–450. https://doi.org/10.1093/clinchem/hvaf155

Endogenous Lithium Levels and Alzheimer Disease

Raymond T Suhandynata, Elizabeth A Bevins, Imir G Metushi. Endogenous Lithium Levels and Alzheimer Disease. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 424–425. https://doi.org/10.1093/clinchem/hvaf174

Audio Summary April 2026

PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening

David H Wang. PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 328–330. https://doi.org/10.1093/clinchem/hvaf137

A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready?

Leslie J Donato. A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 222–224. https://doi.org/10.1093/clinchem/hvaf101