AI + a16z

How Foundation Models Evolved: A PhD Journey Through AI's Breakthrough Era

Nov 18, 2025 · 57 min · Episode 65 · 54.8 MB
0:00-57:06

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The Stanford PhD who built DSPy thought he was just creating better prompts—until he realized he'd accidentally invented a new paradigm that makes LLMs actually programmable. 

While everyone obsesses over whether LLMs will get us to AGI, Omar Khattab is solving a more urgent problem: the gap between what you want AI to do and your ability to tell it, the absence of a real programming language for intent. He argues the entire field has been approaching this backwards, treating natural language prompts as the interface when we actually need something between imperative code and pure English, and the implications could determine whether AI systems remain unpredictable black boxes or become the reliable infrastructure layer everyone's betting on.

Follow Omar Khattab on X: https://x.com/lateinteraction

Follow Martin Casado on X: https://x.com/martin_casado

 

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